Antibacterials with Novel Chemical Scaffolds in Clinical Development

authored by: Dominik Heimann, Daniel Kohnhäuser, Alexandra Jana Kohnhäuser, Mark Brönstrup
Abstract: The rise of antimicrobial resistance represents a significant global health threat, driven by the diminishing efficacy of existing antibiotics, a lack of novel antibacterials entering the market, and an over- or misuse of existing antibiotics, which accelerates the evolution of resistant bacterial strains. This review focuses on innovative therapies by highlighting 19 novel antibacterials in clinical development as of June 2024. These selected compounds are characterized by new chemical scaffolds, novel molecular targets, and/or unique mechanisms of action, which render their potential to break antimicrobial resistance particularly high. A detailed analysis of the scientific foundations behind each of these compounds is provided, including their pharmacodynamic profiles, current development state, and potential for overcoming existing limitations in antibiotic therapy. By presenting this subset of chemically novel antibacterials, the review highlights the ability to innovate in antibiotic drug development to counteract bacterial resistance and improve treatment outcomes.
Organisation(s): Centre of Biomolecular Drug Research (BMWZ)
External Organisation(s): Helmholtz Centre for Infection Research (HZI)
German Center for Infection Research (DZIF)
Type: Article
Journal: DRUGS
No. of pages: 31
ISSN: 0012-6667
Publication date: 23.01.2025
Publication status: E-pub ahead of print
Peer reviewed: Yes
ASJC Scopus subject areas: Pharmacology (medical)
Electronic version(s): https://doi.org/10.1007/s40265-024-02137-x (Access: Open)

BibTeX

@article{61ef16a197b9493f897505c191c3876a,
title = "Antibacterials with Novel Chemical Scaffolds in Clinical Development",
abstract = "The rise of antimicrobial resistance represents a significant global health threat, driven by the diminishing efficacy of existing antibiotics, a lack of novel antibacterials entering the market, and an over- or misuse of existing antibiotics, which accelerates the evolution of resistant bacterial strains. This review focuses on innovative therapies by highlighting 19 novel antibacterials in clinical development as of June 2024. These selected compounds are characterized by new chemical scaffolds, novel molecular targets, and/or unique mechanisms of action, which render their potential to break antimicrobial resistance particularly high. A detailed analysis of the scientific foundations behind each of these compounds is provided, including their pharmacodynamic profiles, current development state, and potential for overcoming existing limitations in antibiotic therapy. By presenting this subset of chemically novel antibacterials, the review highlights the ability to innovate in antibiotic drug development to counteract bacterial resistance and improve treatment outcomes.",
author = "Dominik Heimann and Daniel Kohnh{\"a}user and Kohnh{\"a}user, {Alexandra Jana} and Mark Br{\"o}nstrup",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",
year = "2025",
month = jan,
day = "23",
doi = "10.1007/s40265-024-02137-x",
language = "English",
journal = "DRUGS",
issn = "0012-6667",
publisher = "Adis International Ltd",
}